The calcium-cancer signalling nexus.
Identifieur interne : 000233 ( Main/Exploration ); précédent : 000232; suivant : 000234The calcium-cancer signalling nexus.
Auteurs : Gregory R. Monteith [Australie] ; Natalia Prevarskaya [France] ; Sarah J. Roberts-Thomson [Australie]Source :
- Nature reviews. Cancer [ 1474-1768 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs.
- physiologie : Signalisation du calcium.
- étiologie : Tumeurs.
- Humains, Tumeurs.
English descriptors
- KwdEn :
- MESH :
- etiology : Neoplasms.
- pathology : Neoplasms.
- physiology : Calcium Signaling.
- therapy : Neoplasms.
- Humans.
Abstract
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past decade there has been a deeper understanding of how calcium signalling is remodelled in some cancers and the consequences of calcium signalling on key events such as proliferation, invasion and sensitivity to cell death. Specific calcium signalling pathways have also now been identified as playing important roles in the establishment and maintenance of multidrug resistance and the tumour microenvironment.
DOI: 10.1038/nrc.2017.18
PubMed: 28386091
Affiliations:
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Le document en format XML
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Monteith</name><affiliation wicri:level="1"><nlm:affiliation>The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Queensland 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Queensland 4102</wicri:regionArea><wicri:noRegion>Queensland 4102</wicri:noRegion></affiliation></author><author><name sortKey="Prevarskaya, Natalia" sort="Prevarskaya, Natalia" uniqKey="Prevarskaya N" first="Natalia" last="Prevarskaya">Natalia Prevarskaya</name><affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale U1003, Laboratoire de Physiologie Cellulaire, Equipe labellisée par la Ligue contre le cancer, and Universite de Lille 1, Villeneuve d'Ascq, F-59650, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale U1003, Laboratoire de Physiologie Cellulaire, Equipe labellisée par la Ligue contre le cancer, and Universite de Lille 1, Villeneuve d'Ascq, F-59650</wicri:regionArea><wicri:noRegion>59650</wicri:noRegion><wicri:noRegion>59650</wicri:noRegion></affiliation></author><author><name sortKey="Roberts Thomson, Sarah J" sort="Roberts Thomson, Sarah J" uniqKey="Roberts Thomson S" first="Sarah J" last="Roberts-Thomson">Sarah J. Roberts-Thomson</name><affiliation wicri:level="1"><nlm:affiliation>The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Queensland 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Queensland 4102</wicri:regionArea><wicri:noRegion>Queensland 4102</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature reviews. 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Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past decade there has been a deeper understanding of how calcium signalling is remodelled in some cancers and the consequences of calcium signalling on key events such as proliferation, invasion and sensitivity to cell death. Specific calcium signalling pathways have also now been identified as playing important roles in the establishment and maintenance of multidrug resistance and the tumour microenvironment.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Monteith, Gregory R" sort="Monteith, Gregory R" uniqKey="Monteith G" first="Gregory R" last="Monteith">Gregory R. Monteith</name></noRegion><name sortKey="Roberts Thomson, Sarah J" sort="Roberts Thomson, Sarah J" uniqKey="Roberts Thomson S" first="Sarah J" last="Roberts-Thomson">Sarah J. Roberts-Thomson</name></country><country name="France"><noRegion><name sortKey="Prevarskaya, Natalia" sort="Prevarskaya, Natalia" uniqKey="Prevarskaya N" first="Natalia" last="Prevarskaya">Natalia Prevarskaya</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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